Universidad Pontificia Bolivariana. Guevara M, Gines P. Hyponatremia in liver cirrhosis: patho- genesis and treatment. Endocrinol Nutr ;57 Suppl 2
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Rev Col Gastroenterol [online]. ISSN Patients with advanced liver disease may present volume overloads that can lead to the development of dilutional hyponatremia primarily as the result of persistently high levels of antidiuretic hormone. Liver transplantation is the therapy of choice for patients with terminal liver disease. Patient survival time following transplantation is excellent. Dilutional hyponatremia has proven to be a prognostic factor for patients with cirrhosis, and it can even lead to mortality in patients on the waiting list for liver transplantation.
Hiponatremia dilucional y trasplante hepático. Revisión
Hyponatremia is the most common electrolyte disorder in patients with cirrhosis. In dilutional or hypervolemic hyponatremia, serum sodium concentration is reduced, plasma volume is increased although the effective plasma volume is decreased due to marked arterial vasodilation in the splanchnic circulation and extracellular fluid volume is increased, with ascites and edema in the absence of signs of dehydration. This is a result of the marked deterioration in renal excretion of solute-free water, leading to disproportionate water retention in relation to sodium retention. Since hypervolemic hyponatremia is by far the most frequent form of this disorder, the present chapter will concentrate specifically on hypervolemic hyponatremia in cirrhosis.. ISSN: Hyponatremia in liver cirrhosis: pathogenesis and treatment. Descargar PDF.